Category: BCM441

Retinoids: A future class of antibiotics?

Retinoids: A future class of antibiotics?

Link to paper: doi:10.1038/nature26157 Antibiotics have revolutionized 20th-century medicine. Bacterial infections that were once life-threatening are no longer considered fatal with the administration of this class of drugs. However, microbes are survivors, and from this solved problem arises a new one – resistant bacterial strains. […]

Capstone Project: Crohn’s Disease

Capstone Project: Crohn’s Disease

Crohn’s disease is often associated with stomach issues. But what exactly is it? Crohn’s disease (CD) is an inflammatory bowel disorder (IBD) that currently affects around half a million people in the US. It typically impacts the colon but can also affect any part of […]

Literature Search Themes

Themes that have emerged from the literature search: 1. Characterization of CD Crohn, B.B., Ginzburg, L., Oppenheimer, G.D., 1932. Regional Ileitis: A Pathological and Clinical Entity. JAMA 99, 1323–1329. https://doi.org/10.1001/jama.1932.02740680019005 Hadfield, G., 1939. The Primary Histological Lesion of Regional Ileitis. The Lancet 234, Issue 6058, 773–776. https://doi.org/10.1016/S0140-6736(00)62866-0 Warren, S., Sommers, S.C., […]

Gut Microbiota: a potential target for therapeutics

Gut Microbiota: a potential target for therapeutics

Link to article: https://pubs.acs.org/doi/10.1021/acschembio.8b00309 Gut microbiota play both versatile and critical roles in the human body. Not only do they help in immune responses, but also contribute to energy metabolism by degrading complex carbohydrates for which humans do not possess the enzymes.1 These symbiotic microorganisms […]

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